Fig 8.

Pathway representation of canonical and Pyk2-mediated TLR9 signaling. Shown are signaling pathways based on known phosphorylation events of TLR9. A coloring scheme is used to illustrate phosphorylation events that were detected with the peptide array when analyzing lysates from bovine monocytes stimulated with CpG ODNs in the presence (B) and absence (A) of M. avium subsp. paratuberculosis infection. Differential levels of phosphorylation relative to the medium-treated control (P < 0.1) are presented as green for increased phosphorylation, red for decreased phosphorylation, and blue for insignificant phosphorylation or peptide not present on array.