Table 2.

Increase in isotype responses to SWA, SmTAL1, SEA, SmTAL2, AHW, and ASP2 following treatment among all children by age group

Antigen and antibody	All children		Children ≤10 yr of age		Children >10 yr of age
	% boosta (95% CI)	P valueb	% boost (95% CI)	P value	% boost (95% CI)	P value
SWA
IgE	7 (1, 13)	0.03	6 (−2, 14)	0.14	7 (−2, 17)	0.12
IgG1	69 (59, 81)	<0.0001	71 (56, 88)	<0.0001	68 (53, 84)	<0.0001
IgG4	83 (54, 118)	<0.0001	101 (57, 157)	<0.0001	68 (30, 116)	<0.0001
TAL1
IgE	30 (11, 51)	0.001	3 (−13, 23)	0.70	61 (26, 107)	0.0002
IgG1	31 (17, 46)	<0.0001	12 (−1, 28)	0.09	52 (28, 80)	<0.0001
IgG4	58 (37, 81)	<0.0001	26 (11, 42)	0.0003	96 (54, 150)	<0.0001
SEA
IgE	4 (−3, 12)	0.23	7 (−3, 17)	0.19	2 (−8, 13)	0.67
IgG1	−7 (−11, −2)	0.004	−4 (−11, 3)	0.23	−10 (−16, −3)	0.01
IgG4	−18 (−28, −8)	0.001	−8 (−22, 7)	0.27	−27 (−39, −13)	0.001
TAL2
IgE	2 (−14, 20)	0.86	3 (−18, 30)	0.77	0 (−22, 28)	0.99
IgG1	−5 (−11, 2)	0.17	−9 (−18, 1)	0.09	0 (−8, 8)	0.94
IgG4	17 (7, 28)	0.001	17 (1, 36)	0.04	17 (4, 31)	0.01
AHW
IgE	1 (−30, 44)	0.97	−14 (−42, 27)	0.44	18 (−35, 115)	0.59
IgG1	−68 (−79, −51)	<0.0001	−70 (−84, −42)	0.001	−67 (−81, −41)	0.0003
IgG4	−17 (−22, −11)	<0.0001	−17 (−24, −9)	0.0001	−17 (−24, −9)	0.0001
ASP2
IgE
IgG1	−6 (−15, 4)	0.24	−12 (−24, 1)	0.08	1 (−12, 16)	0.89
IgG4	−6 (−22, 15)	0.56	−11 (−33, 19)	0.44	0 (−23, 30)	0.97

^aAverage percent increase in antibody responses, calculated as follows: 100 × (exp{mean[ln(posttreatment level + assay cutoff) − ln(pretreatment level + assay cutoff)]} − 1).

^bPaired t test comparing ln(posttreatment level + assay cutoff) with ln(pretreatment level + assay cutoff).