Table 1.
Signs of disease in Y. pseudotuberculosis-infected mice
| Day | Disease severitya in mice infected with various Y. pseudotuberculosis strains |
|||
|---|---|---|---|---|
| Wild type | Wild type, PMN− | yopK mutant | yopK mutant, PMN− | |
| 1 | – | – | – | – |
| 3 | + | ++ | – | + |
| 5 | +++ | ++ | – | +++ |
| 7 | +++ | +++ | – | +++ |
a
Disease severity was graded based on visual inspections of each mouse for symptoms such as ruffled fur, hunchback posture, and diarrhea. –, Healthy mice without any signs of disease; +, at least 50% of the mice showed signs of ruffled fur; ++, the majority of the mice had ruffled fur and diarrhea; +++, the majority of the mice had severe diarrhea and a hunchback posture.