Fig 1.

UPEC elicits significant host transcriptional changes in the bladder. Complete linkage cluster (A) and heat map (B) of all of the 2,200 unique BioIDs that were significantly different in any of the five comparisons in Table S1 in the supplemental material. Red, an increase in gene expression relative to the control; green, a decrease in gene expression relative to the control. (C) Complete linkage cluster of 783 BioIDs from CP9-versus-CP9cnf1 and/or CP9-versus-CP9ΔhlyA₁ comparisons. For complete linkage clusters, gene expression relative to the reference control (normal bladder RNA) is shown for RNA isolated from the bladder of each mouse challenged with CP9 (CP9), CP9cnf1 (cnf1), CP9ΔhlyA₁ (hlyA), or PBS (PBS).