Table 4.
Comparison of ICS test and CAD kit results during antibiotic treatment in the mouse pneumonia model
| Test resulta | No. of results on day: |
|||||||
|---|---|---|---|---|---|---|---|---|
| ICS test |
CAD kit |
|||||||
| 2 (n = 10)b | 4 (n = 10) | 7 (n = 8) | 9 (n = 8) | 2 (n = 10) | 4 (n = 10) | 7 (n = 8) | 9 (n = 8) | |
| − | 2 | 9 | 8 | 8 | 1 | 5 | 6 | 5 |
| ± | 5 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
| + | 3 | 0 | 0 | 0 | 8 | 4 | 1 | 3 |
a
The performances of the ICS test and CAD kit in urine were evaluated at days 2, 4, 7, and 9 after infection of CBA/JN mice with S. pneumoniae at 106 CFU/ml. CBA/JN mice infected with S. pneumoniae were treated with IPM/CS 2 times a day starting at day 3 postinfection and continuing for 7 days. +, positive; −, negative; ±, low-intensity lines that might be weakly positive (a faint line in comparison with the control line) or negative.
b
n, number of mice tested.