Fig 8.
AZD8055 improves muscle mass and reduces abnormal desmin accumulation in Mtm1gt/y muscle. (A) Weights of muscles from WT or Mtm1gt/y mice treated with AZD8055 for 3 days. The number of animals per group is indicated in the graph. Values are means ± standard deviations (*, P < 0.05; ***, P < 0.001 [relative to vehicle-treated Mtm1gt/y mice]; ##, P < 0.01 [relative to AZD8055-treated Mtm1gt/y mice]; n ≥ 3 mice per group). MW, muscle weight; BW, body weight. (B) Mice were treated with the vehicle or AZD8055 for 2 weeks. Protein lysates were extracted from muscle for immunoblot analysis for desmin. Relative band intensities were quantified and are represented in the graph. Values are means ± standard deviations (**, P < 0.01 [relative to vehicle-treated Mtm1gt/y mice]).