Table 2.
Viremia in vaccinated and control mice after challenge with CHIKV
| Immunization group | Virus titer (log10 PFU/ml ± SD)a |
|||
|---|---|---|---|---|
| Day 1 | Day 2 | Day 3 | Day 4 | |
| rwt-VSV | 2.55 ± 0.56 (2/4) | 2.85 ± 0.47 (4/4) | <0.9 (0/4) | 2.0 ± 0.0 (1/4) |
| VSV-CHIKV | <0.9 (0/4) | <0.9 (0/4) | <0.9 (0/4) | <0.9 (0/4) |
| VSVΔG-CHIKV | <0.9 (0/4) | <0.9 (0/4) | <0.9 (0/4) | <0.9 (0/4) |
a
Mice were challenged with 104 PFU of CHIKV-LR administered s.c. in the rear left footpad. Four mice from each immunization group were bled on alternate days postchallenge, i.e., either on days 1 and 3 postchallenge or on days 2 and 4 postchallenge. Values in parentheses indicate the number of positive mice/total number of mice in group.