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Macrophage-tropic R5 Env+ pseudovirions are significantly more resistant to PG9 neutralization but not to PG16. Mann-Whitney analyses comparing macrophage-tropic and non-macrophage-tropic Env+ pseudovirions for sensitivity to MAbs PG9 and PG16 (which recognize a quaternary epitope comprising determinants in V2 and V3), are shown.
