Fig 5.

Macrophage-tropic R5 Env⁺ pseudovirions do not significantly differ from non-macrophage-tropic Envs in sensitivity to maraviroc, T20, 2F5, and 4E10. However, macrophage-tropic R5 Envs are significantly more resistant to neutralization by the glycan-specific MAb 2G12. Mann-Whitney analyses comparing macrophage-tropic and non-macrophage-tropic Env⁺ pseudovirions for sensitivity to the CCR5 antagonist maraviroc, the 6-helix bundle inhibitor T20, gp41 MAbs 4E10 and 2F5, and the gp120 glycan-specific MAb 2G12 are shown.