Table 2.
Integration sites in control and LEDGF/p75 knockout MEFs
| Genomic feature | Value at each integration sitea |
||||
|---|---|---|---|---|---|
| WT_WT (n = 273,049) | N74D_WT (n = 524,372) | WT_Psip1−/− (n = 92,475) | N74D_Psip1−/− (n = 440,756) | Random (n = 100,000) | |
| Transcription unitsb,c | 200,760 (73.5) | 309,381 (59.0) | 45,695 (49.4) | 171,574 (39.0) | 33,031 (33.0) |
| No. of promoters (±1 kb)c | 1,866 (0.68) | 2,636 (0.50) | 3,540 (3.83) | 10,065 (2.28) | 1,595 (1.60) |
| No. of CpG islands (±1 kb)c | 1,428 (0.52) | 882 (0.17) | 2,422 (2.62) | 4,884 (1.11) | 728 (0.73) |
| Genes per 1 Mb | 18.2 | 7.7 | 14.8 | 8.0 | 8.7 |
| Transcriptional activityd | 587 | 222 | 464 | 231 | 249 |
a
Percentage values are indicated in parentheses.
b
Refseq genes from mouse genome build mm9, UCSC Genome Bioinformatics website (http://genome.ucsc.edu/).
c
Pairwise comparisons by Fisher's exact test in all cases yielded P values of <0.0001.
d
Total RNA tag counts per Mb surrounding each integration site.