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Addition of the heterologous VP16 transactivation domain to Rta deletion mutants restores the capacity of Rta to activate expression of BMRF1 by synergy with Z(S186A). Western blot analysis of BZKO cells expressing Z(S186A) together with full-length or mutated Rta with or without VP16 fusions is shown. Cells were harvested after 48 h. The membrane was blotted with antibodies against Rta and BMRF1.
