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. 2013 Jan;141(1):61–72. doi: 10.1085/jgp.201210899

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© 2013 Terrenoire et al.

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Figure 6. — hERG K897T polymorphism does not alter biophysical properties of hERG channels in iPSC-CMs. (A) I_Kr currents recorded from father (897K/K), mother (897T/T), and proband (897K/T) iPSC-CMs during 2-s pulses (0.1 Hz) to −40, −10, and 20 mV and for 2 s after return to a −40-mV holding potential. Dashed lines, zero current. (B and C) Current versus test pulse voltage. (B) Current measured at 2 s during test pulse (n = 4–15). (C) Normalized tail current measured at −40 mV (n = 12–22). (D) Bar graph summary showing I_Kr midpoint of activation (V_1/2) for each clone tested and calculated from a Boltzmann fit of normalized tail current. Data are shown as means ± SEM.