Table 1.
Enriched molecular functions of compared Drosophila melanogaster maternal genes
| Group | GO term | P-value | Sample frequency | Background frequency |
|---|---|---|---|---|
| A |
small molecule binding (GO:0036094) |
5.17e-08 |
525/3235 (16.2%) |
552/3718 (14.8%) |
| |
nucleoside phosphate binding (GO:1901265) |
1.24e-07 |
486/3235 (15.0%) |
510/3718 (13.7%) |
| |
nucleotide binding (GO:0000166) |
1.24e-07 |
486/3235 (15.0%) |
510/3718 (13.7%) |
| |
organic cyclic compound binding (GO:0097159) |
1.24e-07 |
486/3235 (15.0%) |
510/3718 (13.7%) |
| B |
sequence-specific DNA binding transcription factor activity (GO:0003700) |
5.44e-04 |
35/184 (19.0%) |
290/3718 (7.8%) |
| |
nucleic acid binding transcription factor activity (GO:0001071) |
5.44e-04 |
35/184 (19.0%) |
290/3718 (7.8%) |
| |
structural constituent of chitin-based cuticle (GO:0005214) |
4.36e-03 |
11/184 (6.0%) |
41/3718 (1.1%) |
| |
structural constituent of cuticle (GO:0042302) |
7.28e-03 |
11/184 (6.0%) |
43/3718 (1.2%) |
| C |
endopeptidase activity (GO:0004175) |
6.26e-10 |
37/299 (12.4%) |
124/3718 (3.3%) |
| |
serine-type endopeptidase activity (GO:0004252) |
5.99e-09 |
21/299 (7.0%) |
45/3718 (1.2%) |
| |
peptidase activity, acting on L-amino acid peptides (GO:0070011) |
8.20e-08 |
41/299 (13.7%) |
171/3718 (4.6%) |
| serine-type peptidase activity (GO:0008236) | 4.22e-07 | 21/299 (7.0%) | 54/3718 (1.5%) |
The four enriched molecular function terms with the lowest p-values for each group within the comparison of the Berkeley Drosophila Genome Project in situ database maternal genes to the T. castaneum findings. Group A consists of D. melanogaster maternal genes with T castaneum maternally loaded orthologs. Group B consists of D. melanogaster maternal genes with T. castaneum orthologs which were expressed in fertilized eggs but not maternally loaded. Group C consists of Drosophila melanogaster maternal genes with T. castaneum orthologs which were not expressed in eggs.