Table 2.
Differentially methylated (DM) genes identified as falling within the top networks using IPA pathway analysis (a) between all cases and controls, and (b) between MTX-naïve cases and controls
| Top network functions | # DM genes | Genes | |
|---|---|---|---|
|
(a) |
Immunological disease, cardiac hypertrophy, cardiovascular disease |
21 |
APOE, ATP2B4, CARD8, CASP8, CAV3, COL17A1, DOK2, ESR2, HRSP12, IL1RL1, ITGA6, MEF2C, NR1D1, NR1I2, PLUNC, PSMC5, RETN, SELL, SPA17, SPOP, TLR6 |
| |
Cellular Growth and Proliferation, Gene Expression, Cellular Movement |
16 |
ANGEL2, ARMC1, C11orf49, CBARA1, FXC1, KIAA0196, KRT10, LCN12, MRPL28, MTRF1, NR1D1, PSMB5, PSMC5, RBM18, RSL24D1, TFB1M |
| |
Antigen Presentation, Cell-To-Cell Signaling and Interaction, Hematological System Development and Function |
15 |
AKAP6, ARFGEF1, BCKDHB, CDS2, CEACAM3, CPT2,CRB1, GCET2, GPD2, LY9, RAB32,RBP3, SLC1A6, TIMM8B, ZKSCAN3 |
| (b) | Cellular growth and proliferation, Haematological system development and function, Hematopoiesis | 9 | HCRTR1, HOXB4, IL32, LIN37, MEP1A, NDUFB10, PRKRA, RCAN2, SOCS2 |