Table 2.
Main results of pooled odds ratios (ORs) with confidence interval (CI) in the meta-analysis
| Variables | No. of studies | |
Ala/Ala vs Val/Val |
|
|
Ala/Ala vs Ala/Val |
|
|
Ala/Val vs Val/Val |
|
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | Ph | P | OR (95% CI) | Ph | P | OR (95% CI) | Ph | P | ||
| Total |
51 |
0.870(0.789 0.958) |
0.001 |
0.005 |
0.969(0.923 1.016) |
0.206 |
0.191 |
0.895(0.821 0.976) |
0.021 |
0.012 |
| Asian |
19 |
0.787(0.645 0.961) |
0.017 |
0.019 |
0.929(0.843 1.023) |
0.212 |
0.132 |
0.865(0.753 0.993) |
0.300 |
0.039 |
| Caucasian |
25 |
0.869(0.741 1.020) |
0.040 |
0.319 |
1.004(0.921 1.095) |
0.137 |
0.926 |
0.910(0.778 1.064) |
0.031 |
0.238 |
| Mixed |
7 |
0.925(0.793 1.079) |
0.050 |
0.087 |
0.958(0.898 1.022) |
0.946 |
0.191 |
0.912(0.778 1.068) |
0.050 |
0.253 |
|
Variables |
No. of studies |
Ala/Val + Ala/Val vs Val/Va (dominant) |
Ala/Ala vs Ala/Val + Val/Va (recessive) |
Ala allele vs Val allele |
||||||
|
OR (95% CI) |
Ph |
P |
OR (95% CI) |
Ph |
P |
OR (95% CI) |
Ph |
P |
||
| Total |
51 |
0.882(0.808 0.963) |
0.004 |
0.005 |
0.944(0.898 0.993) |
0.055 |
0.026 |
0.935(0.887 0.986) |
0.000 |
0.013 |
| Asian |
19 |
0.826(0.703 0.972) |
0.075 |
0.021 |
0.890(0.799 0.991) |
0.043 |
0.034 |
0.877(0.801 0.960) |
0.003 |
0.008 |
| Caucasian |
25 |
0.916(0.790 1.063) |
0.030 |
0.247 |
0.985(0.908 1.069) |
0.141 |
0.720 |
0.883(0.805 0.968) |
0.052 |
0.359 |
| Mixed | 7 | 0.888(0.758 1.041) | 0.029 | 0.144 | 0.946(0.890 1.006) | 0.773 | 0.076 | 0.957(0.838 1.094) | 0.000 | 0.523 |
Ph: P value of Q-test for heterogeneity test.