Table 6.
Predictors of adverse outcome, logistic regression analysis
|
Characteristic |
Good outcome |
Adverse outcome |
Univariate |
Multivariate, OR, 95% CI, p-value |
|---|---|---|---|---|
| GOS > 3, alive | GOS≤3/death | OR, 95% CI | ||
| Age, mean (SD) |
45 (15.9) |
52 (15.6) |
1.03, 1.0-1.06 |
1.02,0.98-1.07, p=0.28 |
| No predisposing factors |
48 |
7 (13%) |
3.5, 1.3-9.4 |
9.3, 1.6-54.7, p=0.014 |
| Comorbidity |
31 |
16 (34%) |
|
|
| GCS at presentation |
|
|
|
|
| 12-15 |
68 |
11(14%) |
1.0 |
1.0 |
| 8-11 |
7 |
3 (30%) |
1.7, 0.6-12 |
3.5, 0.7-17.5, p=0.113 |
| <8 |
1 |
8 (89%) |
26.5, 3.6-381 |
80.6, 2.5-2574, p=0.013 |
| Burr hole aspiration |
54 (79%) |
14 (21%) |
1.0 |
|
| Craniotomy |
17 (81%) |
4 (19%) |
0.9, 0.3-3.1 |
|
| Medical |
8 (62%) |
5 (38%) |
2.4, 0.7-8.5 |
|
| Duration of symptoms before admission, days median (IQR) |
4.0 (0–10) |
3.0 (0–7) |
0.99, 0.97-1.03 |
|
| Time from admission to surgery, days median (IQR) |
5.0 (1–13) |
7.0 (1–14) |
1.02, 0.97-1.07 |
|
| Intraventricular rupture of brain abscess |
4 (40%) |
6 (60%) |
6.6 ,1.7-26.2 |
11.5, 2.5-53.2, p=0.002 |
| Meningitis* |
20 (25%) |
11 (48%) |
2.7, 1.03-7.1 |
1.5, 0.3-6.3, p=0.597 |
| Streptococcus species |
45 (82%) |
10 (18%) |
|
|
| Staphylococci |
9 (60%) |
6 (40%) |
|
|
| Gram-negative species |
5 (83%) |
1 (17%) |
|
|
| Anaerobic bacteria |
7 (87%) |
1 (13%) |
|
|
| Other |
4 (100%) |
0 |
|
|
| Negative culture |
9 (54%) |
5 (36%) |
|
|
| Total n | 79 (77%) | 23 (23%) |
GOS: Glasgow Outcome score, GCS: Glasgow Coma Score, IQR: Inter quartile range. Bacterial species were omitted from logistic regression analysis due to limited number in each group and no significant difference in outcome in univariate analysis. *: Defined as positive spinal fluid culture and/or elevated CSF leukocytes (>15 cells/ μl).