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. 2013 Jan 3;9(1):e1003123. doi: 10.1371/journal.pgen.1003123

Figure 7. Simulation results, episodic selection for persistence in continuous culture.

Figure 7

Bacteria that do and do not produce persisters, respectively N (red) and M (blue). The density of the persister population denoted by the green line. Common parameter values: g = 0.01, VMAX = 1.0, VMIN = −2.0, MIC = 1, κ = 1, epi = 0.001, and Amax  = 50 µg/ml, da = 0.10 hr-1, w = 0.2 hr. for both N and M. Save for (D), f = 2×10−4 per cell per hour and in all simulations there are no persisters at time 0. (A) Changes in the density of M (blue) and N (Red) and the total persisters (Green) with initially equal densities (N = M = 5×108). (B) Same as (A) but initially N = 106 and M = 109). (C) Same as (B) but with N = 103 and M = 109 initially. (D) Same as (C) but f = 2×10−5 per cell per hour.