Figure 2. Molecular interactions between PcTx1 and cASIC1. The superposition of the structure obtained by Dawson et al. (PDB ID 3S3X, blue) and the low-pH structure obtained by Baconguis and Gouaux (PDB ID 4FZ0, red) is shown in cartoon representation. PcTx1 is shown in solvent-accessible surface representation (Dawson in green and Baconguis in yellow). The discrepancies of the two structures concerning their molecular interactions are illustrated in boxes; for details see text. Blue dashed lines indicate the possible hydrogen bonds in the structure obtained by Dawson et al. and red dashed lines in the structure obtained by Baconguis and Gouaux.