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. 2013 Jan 3;8(1):e53520. doi: 10.1371/journal.pone.0053520

Figure 3. Cerebellar morphology and function are not affected by the AhR invalidation.

Figure 3

(A) The morphology of the cerebellum in both AhR+/+ (left) and AhR−/−mice (right) is similar. Top: The size of the cerebellum and its foliation are normal in AhR−/−, as shown on sagittal sections labeled with anti-calbindin antibodies and counterstained with DAPI. Bottom: Climbing fibers (stained by VGLUT2) properly innervate the dendritic arborization of Purkinje cells (CaBP). Scale bars represent 250 µm (top) and 25 µm (bottom). (B–C) Normalized gain (C) and phase (D) during the visuo-vestibular conflict at 0.5 Hz. The AhR−/− and AhR+/+ mice are capable of adaptation during and after the vestibulo-ocular conflict. Blue lines correspond to the AhR+/+ mice, and red lines correspond to the AhR−/− mice. Asterisk indicates statistical difference between the VOR gain before and after the conflict with p<0.001, # represent the statistical difference between the VOR phase during all the adaptation protocol with p<0.001.