Figure 3. Effect of two MSC treatments on sensorimotor function and lesion size.

Mice received 0.5×10⁶ MSCs or Veh at 3, 10 or 3+10 days post-insult. Because no significant difference was found between Veh groups treated at different time points we pooled all animals into one group. (A) Unimpaired forepaw preference in the CRT at 5 weeks post-HI. Quantification of ipsilateral MAP2 (B) and MBP (C) area loss measured as 1- (ipsi-/contralateral MAP2- or MBP-positive area) at 5 weeks post-HI. Insets show representative examples of MAP2 or MBP staining. Data represent mean ± SEM. Sham n = 7; Veh n = 19; MSC 3+10 d n = 13; MSC 10+17 d n = 11; MSC 10 d n = 17. ***p<0.001 vs. Veh., n.s. = non-significant. Data presented in this figure are results from pooled experiments out of 14 different litters. Treatment groups were randomly distributed between litters.