Table 3. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of esophageal adenocarcinoma among cigarette smokers in the SBES cohort.

	EA/total	Unadjusted HR(95% CI)	Adjusted for age† and gender HR(95% CI)	Adjusted for age†, gender, WHR‡ and NSAID use¶ HR(95% CI)
Ever use
Never	11/144	REF	REF	REF
Ever	34/253	1.87 (0.95–3.69)	1.72 (0.87–3.41)	1.57 (0.78–3.14)
Duration (years)
Nonsmokers	11/144	REF	REF	REF
T1 (0.5-<17)	9/83	1.46 (0.60–3.53)	1.49 (0.61–3.60)	1.41 (0.58–3.42)
T2 (17-<31)	10/82	1.54 (0.66–3.64)	1.43 (0.61–3.39)	1.30 (0.54–3.11)
T3 (31+)	15/88	2.71 (1.24–5.91)	2.25 (1.02–4.94)	2.00 (0.89–4.46)
p-value trend *		0.003	0.03	0.05
Intensity
Nonsmokers	11/144	REF	REF	REF
<1 pack/day	8/87	1.18 (0.47–2.93)	1.16 (0.47–2.88)	1.04 (0.41–2.59)
1 pack/day	13/71	2.64 (1.18–5.90)	2.28 (1.02–5.13)	2.17 (0.96–4.95)
>1 pack/day	13/95	2.01 (0.90–4.49)	1.84 (0.82–4.13)	1.68 (0.74–3.82)
p-value trend *		0.02	0.07	0.10
Cumulative exposure (pack-years)
Nonsmokers	11/144	REF	REF	REF
T1 (0.05-<14)	7/84	1.07 (0.41–2.75)	1.08 (0.42–2.80)	1.04 (0.40–2.69)
T2 (14-<36)	11/84	1.75 (0.76–4.03)	1.64 (0.71–3.80)	1.43 (0.61–3.37)
T3 (36+)	16/85	3.02 (1.40–6.50)	2.48 (1.14–5.42)	2.29 (1.04–5.07)
p-value trend *		0.002	0.02	0.04

^†– Age modeled as a continuous variable,

^‡– WHR modeled as a continuous variable,

^¶– NSAID use modeled as a categorical variable (Current, Former, never).

T1: Tertile 1, T2: Tertile 2, T3: Tertile 3.

^*Test for trend was based on the likelihood-ratio test associated with addition of the variable under consideration in its continuous form.