Table 1. Values of LYMFASIM parameters in models for India and West Africa.
| Parameter value | ||
| Description | India | West Africa |
| Average number of mosquito bites/adult person/month, for areas with low, intermediate and high pre-control Mf prevalence | 1600,1950,2700 | 430, 485, 650 |
| Exposure at birth, fraction of maximum exposurea | 0.26 | 0 |
| Age at which exposure reaches maximuma | 19.1 years | 20.0 years |
| Shape parameter for γ distribution describing individual variation in exposure (mean = 1; a higher value indicates less variability) | 1.13 | 0.26 |
| Function that specifies the number of L3-larvae developing in mosquitoes after a single blood meal as a function of human mf density in 20 µl of blood (m) | (0.089 m)/(1+6.6 m) | 1.67(1-exp(-(0.027 m)1.51) |
| Success ratio: the fraction of incoming L3 larvae that survive and develop into mature adult worms. | 1.03×10−3 | 8.8×10−3 |
| Fraction of L3 larvae, from 1 blood meal, released by a mosquito when it bites | 0.1 | 0.1 |
| Mean life span of parasites in human host | 10.2 years | 10.0 years |
| Shape parameter for the Weibull distribution that describes variation in parasite life span | 2.0 | 2.0 |
| Duration of immature stage of parasite in human host | 8 months | 8 months |
| Fraction of microfilariae surviving per month | 0.9 | 0.9 |
| Number of Mf produced/female parasite/month/20 µl of peripheral blood | 0.61 | 0.58 |
| Scale parameter for sigmoid function relating strength of anti-L3 immunity to experience of infection by L3 | 5.89×10−5 | n.a. |
| Shape parameter for γ distribution describing individual variation in ability to develop anti-L3 immunity | 1.07 | n.a. |
| Duration of immunological memory for anti-L3 immunity | 9.6 months | n.a. |
| Clumping factor for the negative binomial distribution describing variation in mf-counts in 20 µL blood smears from an individual with given mf density. Between brackets: idem, for 60 µL blood smears | 0.345 (1.035) | 0.33 (0.99) |
The table lists parameters related to transmission and parasite development, for which the values may vary between the models. See original publications for a full justification of the parameter values [15], [16].
n.a. = not applicable.
a
Exposure increases with age until a maximum is achieved at a certain age; exposure remains at its maximum level thereafter.