Table 3.
The association between sex-specific tertiles of leptin/adiponectin and hip aBMD changea using linear mixed-effects regression models
| Leptin | Adiponectin | |||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Low (ref) | Middle | High | P Trend | Low (ref) | Middle | High | P Trend | |
| Women | ||||||||
| Unadjusted | −0.52 (−0.60, −0.44) | −0.43 (−0.51, −0.34) | −0.60 (−0.69, −0.51) | 0.983 | −0.50 (−0.57, −0.42) | −0.47 (−0.56, −0.39) | −0.57 (−0.66, −0.48) | 0.886 |
| Age adjusted | −0.51 (−0.59, −0.44) | −0.43 (−0.51, −0.34) | −0.62 (−0.71, −0.53) | 0.758 | −0.51 (−0.59, −0.44) | −0.49 (−0.57, −0.49) | −0.55 (−0.65, −0.46) | 0.518 |
| Age and race adjusted | −0.57 (−0.65, −0.49) | −0.44 (−0.53, −0.36) | −0.57 (−0.66, −0.48) | 0.178 | −0.43 (−0.51, −0.36) | −0.55 (−0.61, −0.44) | −0.65 (−0.74, −0.55)* | 0.043 |
| Age race and BMI adjusted | −0.61 (−0.70, −0.52) | −0.45 (−0.53, −0.36) | −0.52 (−0.63, −0.42) | 0.021 | −0.42 (−0.50, −0.34) | −0.53 (−0.61, −0.44) | −0.66 (−0.76, −0.57)* | 0.015 |
| Base model† | −0.62 (−0.71, −0.53) | −0.45 (0.53, −0.36) | −0.53 (−0.64, −0.43) | 0.023 | −0.41 (−0.50, −0.33) | −0.53 (−0.62, −0.44) | −0.70 (−0.80, −0.59)* | 0.005 |
| Base model† + weight change | −0.60 (−0.70, −0.51) | −0.46 (−0.55, −0.37) | −0.57 (−0.68, −0.46) | 0.134 | −0.43 (−0.51, −0.35) | −0.56 (−0.64, −0.47) | −0.67 (−0.77, −0.58)* | 0.019 |
| Men | ||||||||
| Unadjusted | −0.61 (−0.68, −0.53) | −0.54 (−0.62, −0.46) | −0.56 (0.65, −0.48) | 0.089 | −0.55 (−0.62, −0.48) | −0.51 (−0.59, −0.43) | −0.66 (−0.74, −0.57) | 0.439 |
| Age adjusted | −0.61 (−0.68, −0.53) | −0.55 (−0.62, −0.47) | −0.57 (−0.65, −0.49) | 0.101 | −0.56 (−0.64, −0.49) | −0.51 (−0.59, −0.43) | −0.65 (−0.73, −0.56) | 0.234 |
| Age and race adjusted | −0.61 (−0.69, −0.54) | −0.56 (−0.63, −0.48) | −0.56 (−0.65, −0.48) | 0.064 | −0.54 (−0.61, −0.46) | −0.53 (−0.61, −0.45) | −0.68 (−0.77, −0.60) | 0.149 |
| Age race and BMI adjusted | −0.59 (−0.67, −0.50) | −0.56 (−0.63, −0.48) | −0.59 (−0.68, −0.50) | 0.440 | −0.54 (−0.62, −0.47) | −0.53 (−0.61, −0.45) | −0.67 (−0.76, −0.58) | 0.278 |
| Base model‡ | −0.56 (−0.65, −0.46) | −0.58 (−0.66, −0.49) | −0.67 (−0.78, −0.57) | 0.490 | −0.55 (−0.63, −0.47) | −0.55 (−0.64, −0.47) | −0.71 (−0.80, −0.62) | 0.147 |
| Base model‡ + weight change | −0.60 (−0.69, −0.51) | −0.58 (−0.66, −0.50) | −0.60 (−0.70, −0.51) | 0.427 | −0.55 (−0.63, −0.47) | −0.54 (−0.63, −0.47) | −0.70 (−0.79, −0.61) | 0.148 |
a
Mean annualized % change in aBMD (95% CI);
*
p<0.05 for comparison of high and medium tertiles with low (ref) tertile
†
Adjusted for age, age*time, race, race*time, BMI, BMI*time, diabetes*time, and baseline hip aBMD
‡
Adjusted for age, age*time, race, race*time, BMI, BMI*time, physical activity, lean mass*time, total fat*time, and baseline hip aBMD