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FLNc, Xin and Xirp2 colocalize in all protein aggregates observed in filaminopathy muscle fibers. Immunolocalization studies were performed on frozen serial sections of a skeletal muscle biopsy from a filaminopathy patient using antibodies directed against Xirp2, FLNc and Xin as indicated at the top. The proteins not only colocalize in large (A) but also in fibers containing very small aggregates (B). Bar: 50 μm.
