Table I. Cathepsins identified in rat liver lysate. Listed are the number of unique peptides and the sequence coverage (in brackets) of all cathepsin targets of diol-DCG-04 identified from a rat liver lysate. A full list of identified proteins is given in supplemental Table S3.
| Protein name | Accession number | On-bead digestion | Chemical cleavage |
|---|---|---|---|
| Cathepsin Z | Q9R1T3 | 11 (30%) | 10 (32%) |
| Cathepsin B | P00787 | 11 (28%) | 9 (24%) |
| Cathepsin C | P80067 | 8 (23%) | 7 (22%) |
| Cathepsin H | P00786 | 8 (26%) | 9 (26%) |
| Cathepsin S | Q02765 | 5 (17%) | 3 (15%) |
| Cathepsin J | Q63088 | 5 (14%) | 2 (9.3%) |
| Cathepsin L1 | P07154 | 10 (32%) | 2 (5.4%) |