Table 3.
Univariate analysis for association of baseline OCT features with visual outcomes at 1 year
| # of Subjects at 1 year (N=1105) | VA score at 1 year | Change in VA score at 1 year | ≥3-lines gain from baseline at 1 year | ||||
|---|---|---|---|---|---|---|---|
| Baseline OCT features | n (%) | Mean (SE) | P-value* | Mean (SE) | P-value* | n (%) | P-Value† |
| Retinal thickness (microns) | <0.001 | 0.47 | 0.002 | ||||
| <120 | 112 (10.1%) | 68.8 (1.7) | (<0.001) | 6.4(1.4) | (0.66) | 30(26.8%) | (0.005) |
| 120 to 212 | 581 (52.3%) | 70.0 (0.7) | 7.0(0.6) | 150(25.8%) | |||
| >212 | 407 (36.8%) | 64.9 (0.9) | 8.0(0.7) | 146(35.9%) | |||
| Unknown | 5 (0.5%) | 73.6 (7.9) | 9.0(6.6) | 1 (20.0%) | |||
| As continuous (every 10 microns increase) | −0.31 (0.05) | <0.001 | 0.03(0.04) | 0.49 | 0.009 | ||
| Sub-retinal fluid thickness (microns) | 0.13 | 0.13 | 0.002 | ||||
| 0 | 735 (66.5%) | 67.3 (0.7) | (0.21) | 7.9(0.5) | (0.24) | 242(32.9%) | (0.005) |
| >0 to ≤25 | 92 (8.3%) | 70.1 (1.9) | 7.4(1.5) | 24(26.1%) | |||
| >25 | 273 (24.7%) | 69.3 (1.1) | 5.8(0.9) | 60(22.0%) | |||
| Unknown | 5 (0.5%) | 73.6 (8.0) | 9.0(6.6) | 1 (20.0%) | |||
| As continuous (every 10 microns increase) | −0.06 (0.08) | 0.44 | −0.17 (0.06) | 0.006 | 0.02 | ||
| Subretinal tissue complex thickness (microns) by quartile | <0.001 | 0.04 | <0.001 | ||||
| 1st (>0 to ≤75) | 272 (24.6%) | 72.2 (1.1) | (<0.001) | 5.5(0.9) | (0.07) | 53(19.5%) | (<0.001) |
| 2nd (>75 to ≤160) | 263 (23.8%) | 67.9 (1.1) | 7.3(0.9) | 85(32.3%) | |||
| 3rd (>160 to ≤275) | 282 (25.5%) | 67.3 (1.1) | 9.2(0.9) | 101(35.8%) | |||
| 4th (>275) | 283 (25.6%) | 64.8 (1.1) | 7.2(0.9) | 87(30.7%) | |||
| As continuous (every 10 microns increase) | −0.13 (0.03) | <0.001 | −0.00(0.03) | 0.96 | 0.55 | ||
| Retinal + sub-retinal fluid thickness (microns) by quartiles | <0.001 | 0.49 | 0.17 | ||||
| 1st (≤160) | 274 (24.8%) | 69.8 (1.1) | (<0.001) | 6.6(0.9) | (0.64) | 72(26.3%) | (0.26) |
| 2nd (>160 to ≤225) | 273 (24.7%) | 69.8 (1.1) | 8.4(0.9) | 91(33.3%) | |||
| 3rd (>225 to ≤320) | 279 (25.3%) | 68.6 (1.1) | 6.9(0.9) | 75(26.9%) | |||
| 4th (>320) | 274 (24.8%) | 63.7 (1.1) | 7.4(0.9) | 88(32.1%) | |||
| As continuous (every 10 microns increase) | −0.26 (0.04) | <0.001 | −0.04 (0.04) | 0.31 | 0.30 | ||
| Total foveal thickness (microns) by quartile | <0.001 | 0.08 | 0.004 | ||||
| 1st (≤325) | 277 (25.1%) | 71.6 (1.0) | (<0.001) | 5.8 (0.9) | (0.14) | 59 (21.3%) | (0.008) |
| 2nd (>325 to ≤425) | 285 (25.8%) | 72.2 (1.0) | 8.5 (0.9) | 95 (33.3%) | |||
| 3rd (>425 to ≤550) | 253 (22.9%) | 67.9 (1.1) | 8.4 (0.9) | 83 (32.8%) | |||
| 4th (>550) | 285 (25.8%) | 60.4 (1.0) | 6.6 (0.9) | 89 (31.2%) | |||
| Unknown | 5 (0.5%) | 73.6 (7.7) | 9.0 (6.6) | 1 (20.0%) | |||
| As continuous (every 10 microns increase) | −0.22 (0.03) | <0.001 | −0.02 (0.02) | 0.49 | 0.23 | ||
| Intra-retinal fluid | <0.001 | 0.40 | 0.007 | ||||
| No Fluid | 264 (23.9%) | 72.8 (1.1) | (<0.001) | 6.9 (0.9) | (0.58) | 61 (23.1%) | (0.02) |
| Fluid but not in foveal center point | 298 (27.0%) | 68.7 (1.0) | 6.6 (0.9) | 84 (28.2%) | |||
| Fluid in foveal center point | 525 (47.5%) | 65.4 (0.8) | 8.0 (0.6) | 177 (33.7%) | |||
| Unknown | 18 (1.6%) | 64.0 (4.1) | 6.1 (3.5) | 5 (27.8%) | |||
| Sub-retinal fluid | 0.045 | 0.19 | 0.01 | ||||
| No Fluid | 189 (17.1%) | 65.7 (1.3) | (0.10) | 6.4 (1.1) | (0.20) | 62 (32.8%) | (0.02) |
| Fluid but not in foveal center point | 523 (47.3%) | 67.7 (0.8) | 8.1 (0.6) | 169 (32.3%) | |||
| Fluid in foveal center point | 384 (34.8%) | 69.6 (0.9) | 6.5 (0.8) | 92 (24.0%) | |||
| Unknown | 9 (0.8%) | 65.9 (5.9) | 12.9 (4.9) | 4 (44.4%) | |||
| Sub-RPE fluid | 0.77 | 0.76 | 0.01 | ||||
| No Fluid | 483 (43.7%) | 68.7 (0.8) | (0.41) | 7.5 (0.7) | (0.37) | 163 (33.7%) | (0.02) |
| Fluid but not in foveal center point | 194 (17.6%) | 68.1 (1.3) | 6.9 (1.1) | 50 (25.8%) | |||
| Fluid in foveal center point | 344 (31.1%) | 67.8 (1.0) | 6.7 (0.8) | 86 (25.0%) | |||
| Unknown | 84 (7.6%) | 65.2 (1.9) | 9.8 (1.6) | 28 (33.3%) | |||
| Any fluid in foveal center | 0.03 | 0.26 | 0.050 | ||||
| No Fluid in foveal center point | 201 (18.2%) | 70.5 (1.3) | (0.09) | 8.1 (1.0) | (0.59) | 71 (35.3%) | (0.10) |
| Fluid in foveal center point | 901 (81.5%) | 67.5 (0.6) | 7.1 (0.5) | 255 (28.3%) | |||
| Unknown | 3 (0.3%) | 70.7 (10) | 12.7 (8.5) | 1(33.3%) | |||
| RPE elevation | 0.009 | <0.001 | <0.001 | ||||
| No | 145 (13.1%) | 71.6 (1.5) | (0.03) | 11.2 (1.2) | (<0.001) | 61 (42.1%) | (<0.001) |
| Yes | 944 (85.4%) | 67.5 (0.6) | 6.6 (0.5) | 258 (27.3%) | |||
| Unknown | 16 (1.5%) | 68.3 (4.4) | 14.1 (3.7) | 8 (50.0%) | |||
| RPEE maximum height (mm) by quartiles | |||||||
| 1st (≤3.0) | 317 (28.7%) | 68.6 (1.00) | 0.937 | 7.6 (0.83) | 0.631 | 112 (35.3%) | 0.046 |
| 2nd (>3.0 to ≤5.0) | 212 (19.2%) | 68.9 (1.22) | (0.027) | 8.3 (1.01) | (0.684) | 63 (29.7%) | (0.086) |
| 3rd (>5.0 to ≤11.5) | 267 (24.2%) | 68.1 (1.09) | 7.1 (0.90) | 74 (27.7%) | |||
| 4th (>11.5) | 268 (24.3%) | 68.0 (1.08) | 6.7 (0.90) | 67 (25.0%) | |||
| Unknown | 41 (3.7%) | 59.2 (2.77) | 5.6 (2.30) | 11 (26.8%) | |||
| As continuous (1 mm increase) | −0.05 (0.06) | 0.45 | −0.08 (0.05) | 0.12 | 0.002 | ||
| RPEE maximum width (mm) by quartiles | |||||||
| 1st (≤12.0) | 260 (23.5%) | 69.9 (1.10) | 0.094 | 8.3 (0.91) | 0.069 | 92 (35.4%) | 0.02 |
| 2nd (>12 to ≤31.5) | 250 (22.6%) | 68.5 (1.12) | (0.013) | 6.8 (0.93) | (0.100) | 71 (28.4%) | (0.023) |
| 3rd (>31.5 to ≤55.0) | 258 (23.4%) | 69.0 (1.10) | 8.9 (0.91) | 84 (32.6%) | |||
| 4th (>55.0) | 257 (23.3%) | 66.2 (1.11) | 5.8 (0.91) | 60 (23.3%) | |||
| Unknown | 80 (7.2%) | 63.2 (1.98) | 6.0 (1.64) | 20 (25.0%) | |||
| As continuous (1 mm increase) | −0.03 (0.02) | 0.06 | −0.02 (0.02) | 0.12 | 0.02 | ||
OCT= Optical coherence tomography; VA = Visual Acuity; SE = Standard Error; RPE=Retinal Pigment Epithelium; RPEE=RPE elevation.
*
P-value was from one-way analysis of variance (ANOVA).
†
P-value was from Monte-Carlo fisher exact test.
P-value in the parenthesis was calculated including the unknown category, while P-value not in parenthesis was calculated excluding the unknown category.