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. 2012 Aug 18;91(1):129–139. doi: 10.1007/s00109-012-0942-8

Table 1.

Genes differentially expressed between flow regions in rat and between BAV and TAV

Gene RAT ASAP Flow Function(s) and properties
Disturbed vs uniform flow BAV vs TAV
P value Fold change P value Fold change
ZFP36L1 7.80E−07 −1.24b 0.0101 −1.64 X*4 Zinc finger protein, modulation and destabilization VEGF mRNA, wound healing
ZFP36 1.08Ev−05 −1.37b 2.22E−05 −1.25 X*4 Modulation and destabilization VEGF mRNA, wound healing
FLI1 6.60E−05 1.21 3.66E−06 −1.39 X Angiogenesis, maturation and stabilization of vessels, wound healing
EGR1 7.98E−05 −1.42b 0.000777 −1.31 X Regulates angiopoietin-1 induced EC migration and proliferation, wound healing
IER2 0.00012 −1.19b 0.000429 −1.17 X*4 Mediates EGF-dependent left–right asymmetry patterning in zebrafish
SLC2A3 0.00019 1.36 6.51E−08 −1.44 X*4 Involved in tumour angiogenesis
FOSB 0.00031 −1.51b 1.23E−05 −1.42 X Induced by mechanical stress and cardiac ischemia and VEGF, wound healing
TIMP1 0.00045 1.19 0.00329 −1.17 X Anti-angiogenesis, wound healing
GRK5 0.00053 1.19b 8.30E−05 1.17 X Regulation of vasoconstriction in VSMC, histone deacetylase (HDAC) kinase in cardiomyocytes
CCL2 0.00093 −1.47b 1.32E−06 −1.80 X Involved in neovascularization and angiogenesis, wound healing
NID1 0.00098 −1.14b 0.00197 −1.40 X Ingredient of vascular basement membranes, wound healing
ITGA5 0.00115 −1.19b 9.00E−04 −1.74 X Fibronectin receptor
SOCS3 0.00119 −1.26b 2.84E−07 −1.35 X Negative regulator of cytokines, wound healing
FOS 0.00139 −1.34b 6.31E−05 −1.65 X Regulation of VEGF, angiogenesis, wound healing
KLF2 a 0.00207 −1.29b 0.0105 −1.10 X Regulates VEGFA, angiogenesis
BTG2 0.00314 −1.15b 1.35E−05 −1.30 X Anti-proliferative transcription factor involved in modulation of VEGF-regulated wound repair
SGK1 0.01066 1.10 0.000461 −1.33 X Involved in vascular remodelling during angiogenesis, wound healing
PLEKHO2 0.01227 1.10 6.75E−08 −1.25 ? No functional studies performed according to PubMed
PTGER4 0.01418 −1.29b 1.92E−06 −1.33 X Mediates prostaglandin E2 stimulated VEGF expression, angiogenesis, wound healing
COL6A3 0.01504 1.10 9.00E−05 −1.24 X ECM component, regulated by TGF-β
FERMT2 0.02228 1.10b 0.000179 1.17 ? Wound healing, regulated by TGF-β1, angiogenesis
IL1R1 0.03103 0.0104 −1.21 X Wound healing
PKD2 a 0.04592 7.03E−07 1.30 X Ca2+-permeable channel of cilia, involved in embryonic left right (LR) symmetry, wound healing
GEM 0.13107 0.000193 1.20 X Regulation of voltage-gated Ca2+ channel
DAB2 0.13354 0.000298 −1.30 X*2 Embryonic angiogenesis via VEGF induction, TGF-β-stimulated fibronectin synthesis in wound healing
GPR116 0.18922 1.99E−08 −1.86 X*2 Component of microvasculature
DUSP5 0.27924 8.17E−05 −1.16 X Strongly induced by VEGF in EC, EC specific in vessels development
CEBPB 0.40525 0.000551 −1.12 ? Interacts directly with subunits of NF-kB to augment gene expression by FOS transcription factors
KLF4a 0.44656 8.29E−05 −1.25 X Modulates phenotype of VSMCs, angiogenesis, wound healing
SH2B3 0.48533 8.03E−07 −1.18 ? Stabilization of thrombi within vessels, regulates EPC kinetics in vascular regeneration
JUNB 0.49141 2.60E−05 −1.40 X Regulates VEGF expression in an NF-kB-dependent manner, angiogenesis, wound healing
CDH5 0.53465 2.52E−05 −1.23 X Ingredient of shear stress sensor complex, angiogenesis, EC specific in vessel development
CD93 0.68071 0.000794 −1.22 X*2 Vascular remodelling and angiogenesis
CDKN1A 0.71809 0.002 −1.16 X Involved in regulation of EC senescence and permeability, wound healing
PTPRE 0.79921 4.96E−07 −1.22 X Negative regulation of EC proliferation, possible role in angiogenesis
CALD1 0.93732 0.00108 1.17 X*2 Anti-angiogenesis, cytoskeletal protein, implicated in the migration of EPC
ERG 0.96645 0.00718 1.14 X*2 Angiogenesis, wound healing through regulation of ECM
ELTD1 0.99016 3.03E−05 −1.52 X*4 Specifically expressed in the microvasculature
ENG NA NA 0.000117 −1.42 X Vascular TGF-β co-receptor, angiogenesis, wound healing
PECAM1 NA NA 0.000899 −1.48 X Ingredient of shear stress sensor complex, angiogenesis, wound healing
CEBPD NA NA 0.000296 −1.20 X*4 Interacts with subunits of NF-kB to augment gene expression by FOS transcription factors
THBS1 NA NA 0.00201 −1.37 X Anti-angiogenesis, wound healing
KIAA0247 NA NA 5.25E−05 −1.17 ? Regulator of cell cycle
IL4R NA NA 1.23E−06 −1.34 X IL-4 receptor, IL-4 has been indicated in both promoting and blocking angiogenesis

P values for differential expression between disturbed and uniform flow regions in rat aorta and for genes differentially expressed between BAV and TAV are presented

X induced by shear stress according to the literature, X*2 by KLF2 or X*4 by KLF4 overexpression (extracted from literature search), ? not cited in the literature, NA not analysed

aQuery genes

bFold changes for genes moving in the same direction in BAV and the areas of rat aorta exposed to disturbed flow