Table 6.

Univariate analysis of subcortical volumes using different normalization approaches for AD versus CTL

Subcortical measures	Subcortical volumes
Normalization	Raw	ICV
Third ventricle	ns	p  < 0.01
Fourth ventricle	ns	ns
Inferior lateral ventricle	p < 0.00001	p < 0.00001
Lateral ventricle	p < 0.00001	p < 0.00001
Cerebrospinal fluid (CSF)	P < 0.001	p < 0.00001
Accumbens	p < 0.00001	p < 0.00001
Amygdala	p < 0.00001	p < 0.00001
Brainstem	ns	p < 0.00001
Caudate	ns	ns
Cerebellum cortex	ns	ns
Cerebellum white matter	ns	ns
Corpus callosum anterior	ns	ns
Corpus callosum central	p < 0.001	p < 0.001
Corpus callosum midanterior	p < 0.01	p  < 0.001
Corpus callosum midposterior	p < 0.001	p  < 0.00001
Corpus callosum posterior	ns	p  < 0.01
Hippocampus	p < 0.00001	p < 0.00001
Putamen	ns	ns
Pallidum	ns	ns
Thalamus proper	ns	ns
Ventral diencephalon (DC)	p < 0.001	p  < 0.00001

Bold values illustrate that there are differences in normalization method

AD = Alzheimer’s disease, CTL = healthy control, ICV = intra cranial volume and raw = not normalized. Two-way Student t test with Bonferroni correction is used for univariate analysis. P-values <0.05 considered significant after Bonferroni correction