Table 7.

Univariate analysis of cortical thickness and volumes using different normalization approaches for AD versus CTL

Cortical measures	Cortical thickness			Cortical volume
Normalization	Raw	ICV	Mean CT	Raw	ICV
Banks of superior temporal sulcus	p < 0.00001	p < 0.00001	p < 0.00001	p < 0.00001	p < 0.00001
Caudal anterior cingulate	ns	ns	p < 0.00001	Ns	ns
Caudal middle frontal gyrus	p  < 0.00001	p < 0.001	ns	Ns	ns
Cuneus cortex	ns	ns	p < 0.00001	Ns	ns
Entorhinal cortex	p < 0.00001	p < 0.00001	p < 0.00001	p < 0.00001	p < 0.00001
Fusiform gyrus	p < 0.00001	p < 0.00001	p < 0.00001	p < 0.00001	p < 0.00001
Inferior parietal cortex	p < 0.00001	p < 0.00001	p < 0.00001	p < 0.00001	p < 0.00001
Inferior temporal gyrus	p < 0.00001	p < 0.00001	p < 0.00001	p < 0.00001	p < 0.00001
Isthmus of cingulate cortex	p  < 0.00001	p < 0.001	ns	p < 0.001	p  < 0.00001
Lateral occipital cortex	p  < 0.00001	p < 0.05	ns	Ns	p  < 0.001
Lateral orbitofronral cortex	p  < 0.00001	ns	ns	Ns	p  < 0.05
Lingual gyrus	p  < 0.00001	ns	p < 0.01	p < 0.05	p  < 0.01
Medial orbitalfrontal cortex	p  < 0.00001	p < 0.01	Ns	p < 0.01	p  < 0.00001
Middle temporal gyrus	p < 0.00001	p < 0.00001	p < 0.00001	p < 0.00001	p < 0.00001
Parahippocampal gyrus	p < 0.00001	p < 0.00001	p < 0.00001	p < 0.00001	p < 0.00001
Paracentral sulcus	ns	ns	p < 0.00001	Ns	ns
Frontal operculum	p < 0.00001	ns	p < 0.00001	Ns	ns
Orbital operculum	p  < 0.00001	ns	ns	p < 0.05	p  < 0.01
Triangular part of inferior frontal gyrus	p  < 0.00001	ns	p < 0.01	p < 0.01	p  < 0.001
Pericalcarine cortex	ns	ns	p < 0.00001
Postcentral gyrus	p  < 0.01	ns	p < 0.00001		p  < 0.01
Posterior cingulate cortex	p  < 0.001	ns	p < 0.01	p < 0.01	p  < 0.00001
Precentral gyrus	p  < 0.001	ns
Precuneus cortex	p  < 0.00001	p < 0.00001		p < 0.00001	p < 0.00001
Rostral anterior cingulate cortex	ns	ns	p < 0.01	Ns	ns
Rostral middle frontal gyrus	p  < 0.00001	p < 0.001	ns	p < 0.001	p  < 0.00001
Superior frontal gyrus	p  < 0.00001	p < 0.01	ns	p < 0.01	p  < 0.00001
Superior parietal gyrus	p  < 0.00001	p < 0.01	ns	p < 0.01	p  < 0.00001
Superior temporal gyrus	p  < 0.00001	p < 0.00001	ns	p < 0.00001	p < 0.00001
Supramarginal gyrus	p  < 0.00001	p < 0.00001	ns	p < 0.00001	p < 0.00001
Frontal pole	p  < 0.001	ns	ns	p < 0.001	p < 0.001
Temporal pole	p  < 0.00001	p < 0.00001	ns	p < 0.00001	p < 0.00001
Transverse temporal cortex	ns	ns	ns	Ns	p  < 0.01
Insular	p  < 0.00001	ns	ns	Ns	p  < 0.0001

Bold values illustrate that there are differences in normalization method

AD = Alzheimer’s disease, CTL = healthy control, ICV = intra cranial volume, Raw = not normalized and mean CT = normalized by mean cortical thickness. Two-way Student t test with Bonferroni correction is used for univariate analysis