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. 2012 Nov 29;56(2):350–358. doi: 10.1007/s00125-012-2775-y

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© The Author(s) 2012

Open AccessThis article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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Fig. 2 — (a) Representative sections of paraffin-embedded human grafts stained with the endocrine marker chromogranin A (DAB, brown) in HFD and control-diet mice (scale bar, 50 μm). (b) Morphometric analysis for total endocrine volume (chromogranin A) (HFD [n = 6] vs control [n = 7], >196 sections/group; linear mixed model, see Methods, ***p < 0.001). (c) Sections of paraffin-embedded human grafts stained with the beta cell marker C-peptide (green). (d) Morphometric analysis for beta cell volume (HFD [n = 6] vs control [n = 7], ***p < 0.001). (e) Morphometric analysis for alpha cell volume (HFD [n = 6] vs control [n = 7])