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Acute β-AR or PKA prestimulation blocks Gq-mediated HDAC5 nuclear export. A, comparison of normalized HDAC5-GFP Fnuc/Fcyto at 1 h post-treatment with ET-1 (100 nm) or PE (20 μm) alone or with a 20-min preincubation of forskolin (10 μm) or ISO (100 nm). ***, p < 0.0001. B, HDAC5 translocation in response to dose-dependent NE with or without preincubation of the β-blocker, propranolol (500 nm). **, p < 0.001. ns, not significant. Error bars, S.E.
