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U-73122 significantly inhibited. A, Ca2+ signaling induced by hHK-1. B, migration of U-251 cells induced by hHK-1. C, MMP-2 activity induced by hHK-1. D, protein expression of MMP-2 and MT1-MMP induced by hHK-1. All data were presented as the means ± S.E. for three independent experiments. *, p < 0.001 versus untreated controls (ctl); ###, p < 0.001 versus hHK-1-treated cells.
