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CD44 is not required for amplification of HA synthesis by TSG-6. MASM cells derived from mice homozygous null for CD44 were either not treated (NT) or treated with only TSG-6, poly(I:C), or the simultaneous incubation of poly(I:C) + TSG-6. The U937 leukocyte binding assay was performed on these cultures (A; n = 6). HA attached to the cells (B; n = 6) and secreted into the media (C; n = 6) was quantified by FACE. Error bars represent S.D.
