TABLE 2.

Stimulation of tyrosine phosphorylation of the IGF-IR, IR-A, and IR-B by mature IGF-II and glycosylated IGF-II isoforms

Ligand	IGF-IR		IR-A		IR-B
	EC50	EC50 relative to IGF-II	IC50	EC50 relative to IGF-II	EC50	EC50 relative to IGF-II
	nm	%	nm	%	nm	%
Mature IGF-II	2.37 ± 0.45	100	18.75 ± 3.91	100	6.39 ± 0.19	100
1–87	9.02 ± 1.5	26	128.4 ± 24.6	15	32.92 ± 0.67	19
1–104	4.76 ± 0.4	50	44.86 ± 7.9	42	17.63 ± 3.43	36
1–156	14.68 ± 2	16	244.7 ± 103.7	8	62.84 ± 10.87	10