Table 2.

Summary of association results in the three replication samples

First-step replication: OM sample
CNV	Chr	Freq	P BMI	βa	P body fat mass	βa
CNV1670	10q26.3	0.036	0.0465	1.620	0.0435	2.728
CNV1669	10q26.3	0.036	0.0465	1.620	0.0435	2.728
CNV1834	12p11.21	0.104	0.0510	−0.892	0.0640	−1.378
CNV12144	14q11.2	0.049	0.3220	−0.326	0.4840	0.048
CNV2200	16q23.1	0.012	0.1360	−1.550	0.2440	−1.785

Second-step replication for CNV10q26.3 (CNV1670 and CNV1669)
FHS sample			AA sample
Freq	P BMI	P body fat mass	Freq cases	Freq controls	P obesity	OR (95% CI)
0.046	0.0038	0.593	0.061	0.037	0.0023	1.69 (1.21–2.37)

All P values listed in Table 2 are two-sided raw P values from the association tests. Chr, Chromosome; Freq, frequency for subjects with abnormal copy numbers; OR, odds ratio; CI, confidence interval.

^aFor β, the effect sizes were estimated in kilograms per square meter for BMI and kilograms for body fat mass.