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. 2012 Oct 23;98(1):E185–E190. doi: 10.1210/jc.2012-2471

Table 1.

Results of genetic analyses

Trait SNP Allele MAFa Model 1
 Model 2
 Model 3
 Model 4
OR P value OR P value OR P value OR P value
Qualitative analysis
    LHCGR variants
        Case/control rs7562215 T 0.069 0.71 0.013 0.72 0.044 0.56 0.0036 0.58 8.53 × 10−4
        Case/control rs4319975 A 0.268 1.1 0.192 1.13 0.178 1.11 0.353 1.07 0.493
        Case/control rs10495960 A 0.158 1.31 0.0046 1.36 0.005 1.36 0.024 1.29 0.025
        Case/control rs4952923 G 0.193 1.22 0.022 1.29 0.012 1.26 0.07 1.17 0.125
        Case/control rs17326656 T 0.227 0.9 0.203 0.9 0.279 0.94 0.576 0.98 0.83
        Case/control rs4131886 G 0.264 0.93 0.336 0.94 0.501 0.97 0.811 1 0.996
        Case/control rs4519576 C 0.491 0.89 0.085 0.85 0.039 0.94 0.524 0.99 0.903
        Case/control rs35960650 T 0.349 1.11 0.127 1.15 0.103 1.2 0.078 1.11 0.218
        Case/control rs13405728b NA 0.049 NA NA NA NA NA NA NA NA
        Case/control rs2956355 T 0.093 1.08 0.492 0.96 0.754 0.88 0.45 1.01 0.916
        Case/control rs7562879 A 0.108 0.82 0.068 0.74 0.022 0.7 0.021 0.783 0.065
    FSHR variants
        Case/control rs6739570 T 0.066 1.37 0.038 1.5 0.019 1.36 0.162 1.26 0.202
        Case/control rs10205982 A 0.066 0.73 0.023 0.68 0.021 0.71 0.093 0.74 0.075
        Case/control rs17500266 G 0.46 0.88 0.061 0.88 0.11 0.83 0.07 0.85 0.061
        Case/control rs7591064 C 0.168 1.21 0.021 1.28 0.013 1.3 0.033 1.2 0.071
        Case/control rs11125188 T 0.487 0.87 0.048 0.85 0.041 0.77 0.012 0.82 0.019
        Case/control rs1922476 C 0.359 1.23 0.004 1.23 0.013 1.34 0.005 1.31 0.002
Beta P value Beta P value Beta P value Beta P value
Quantitative analysis
    FSH (mlU/ml) rs17038320 T 0.164 −0.83 1.0 × 10−3 −0.81 1.4 × 10−3 −0.81 1.3 × 10−3 −0.84 9.3 × 10−4
    FSH (mlU/ml) rs17038059 T 0.195 −0.7 3.1 × 10−3 −0.69 3.2 × 10−3 −0.69 3.1 × 10−3 −0.7 3.1 × 10−3
    FSH (mlU/ml) rs17038141 A 0.159 −0.76 3.6 × 10−3 −0.74 4.4 × 10−3 −0.77 3.2 × 10−3 −0.79 2.7 × 10−3
    TG (mg/dl) rs7591064 C 0.168 −24 6.9 × 10−4 −23 1.1 × 10−3 −23 1.1 × 10−3 −24 7.1 × 10−3
    TG (mg/dl) rs4952931 G 0.42 −18 1.8 × 10−3 −18 1.7 × 10−3 −18 1.7 × 10−3 −18 1.8 × 10−3
    TG (mg/dl) rs17500266 G 0.46 18 1.9 × 10−3 17 3.0 × 10−3 17 3.2 × 10−3 18 2.2 × 10−3

Model 1, PCA adjusted; model 2, BMI and PCA adjusted; model 3, age, BMI, and PCA adjusted; model 4, age, and PCA adjusted. NA, Not available, did not genotype.

a

Minor allele frequency in CEU.

b

Chinese PCOS locus.