Fig. 1.
Placental insulin/IGF-I signaling in relation to BMI and birth weight. A, Representative Western blots for total and phosphorylated IRS-1 (Tyr-612) and Akt (Thr-308) in homogenates of placentas from pregnancies with varying maternal BMI and birth weights. There was no significant correlation between BMI or birth weight and total IRS-1 or Akt. B, Relationship between BMI and phosphorylation of placental IRS-1. C and D, Relationship between birth weight and phosphorylation of placental IRS-1 (C) or Akt (D). n = 17; r = Pearson's correlation coefficient.
