TABLE 1.

Summary of Histopathological Findings

Postexposure (days)		Treatment		Total n		Alveolitis		Alveolar histiocytosis		Fibrosis		Phagocytosed NPs
28		DM		6		0 (n = 6)		0 (n = 6)		0 (n = 6)		0 (n = 6)
		7.5 µg NS		5		0 (n = 4)		0 (n = 5)		0 (n = 5)		4 (n = 5)a
						2 (n = 1)
		30 µg NS		7		0 (n = 7)		0 (n = 5)		0 (n = 7)		5 (n = 7)a
								2 (n = 2)
		7.5 µg NB1		5		0 (n = 4)		0 (n = 5)		0 (n = 5)		0 (n = 3)
						2 (n = 1)						2 (n = 1)
												4 (n = 1)
		30 µg NB1		6		0 (n = 5)		0 (n = 2)a		0 (n = 5)		4 (n = 6)a
						3 (n = 1)		3 (n = 2)		2 (n = 1)
								4 (n = 2)
		7.5 µg NB2		6		0 (n = 5)		0 (n = 5)		0 (n = 6)		0 (n = 3)
						2 (n = 1)		3 (n = 1)				4 (n = 3)
		30 µg NB2		7		0 (n = 3)a		0 (n = 5)		0 (n = 4)		0 (n = 5)
						3 (n = 1)		4 (n = 1)		2 (n = 1)		4 (n = 2)
						4 (n = 1)		5 (n = 1)		3 (n = 2)
						5 (n = 2)
112		DM		8		0 (n = 8)		0 (n = 8)		0 (n = 8)		0 (n = 8)
		7.5 µg NS		9		0 (n = 9)		0 (n = 9)		0 (n = 9)		4 (n = 9)a
		30 µg NS		7		0 (n = 7)		0 (n = 5)		0 (n = 7)		4 (n = 7)a
								2 (n = 2)
		7.5 µg NB1		10		0 (n = 9)		0 (n = 10)		0 (n = 9)		0 (n = 7)
						4 (n = 1)				4 (n = 1)		2 (n = 2)
												4 (n = 1)
		30 µg NB1		7		0 (n = 6)		0 (n = 7)		0 (n = 5)		0 (n = 1)a
						3 (n = 1)				2 (n = 1)		2 (n = 3)
										3 (n = 1)		4 (n = 3)
		7.5 µg NB2		8		0 (n = 8)		0 (n = 7)		0 (n = 8)		0 (n = 7)
								6 (n = 1)				2 (n = 1)
		30 µg NB2		7		0 (n = 5)		0 (n = 5)		0 (n = 3)a		0 (n = 4)
						2 (n = 1)		2 (n = 1)		3 (n = 3)		4 (n = 3)
						4 (n = 1)		3 (n = 1)		4 (n = 1)

Note. Values represent histopathology score and inside parentheses the number of animals (n) with that score.

^aSignificant difference between DM (control) and NP exposure group.