TABLE 2.
Mean Body Weight, Survival, Feed Intake, Water Consumption, and Estimated Daily Consumption of Aloe Vera Whole-Leaf Extract, Malic Acid, Aloin A, and Aloe-Emodin Administered to F344/N Rats and B6C3F1 Mice in the Drinking Water for 2 Years
| Male F344/N Rats | Female F344/N Rats | |||||||
|---|---|---|---|---|---|---|---|---|
| Aloe vera whole-leaf concentration (wt/wt) | 0% | 0.5% | 1.0% | 1.5% | 0% | 0.5% | 1.0% | 1.5% |
| Mean bw for study (g) | 457.5 | 452.2 | 436.6*** | 412.7*** | 276.7 | 276.4 | 260.1*** | 238.5*** |
| Mean survival for study (weeks) | 94.4 | 93.0 | 96.3 | 90.0 | 95.7 | 97.6 | 94.6 | 91.9* |
| Mean feed intake (g/day) | 18.9 | 18.5 | 18.6 | 17.8*** | 13.5 | 13.3 | 13.0*** | 12.3*** |
| Mean water consumption (g/day) | 21.7 | 22.5 | 27.0*** | 31.0*** | 17.9 | 18.2 | 19.1 | 20.4** |
| Mean water consumption (g/kg bw/day) | 47.6 | 49.7 | 61.8 | 75.1 | 64.8 | 65.7 | 73.4 | 85.3 |
| Mean Aloe vera whole-leaf extract consumption (g/kg bw/day) | 0 | 0.25 | 0.62 | 1.13 | 0 | 0.33 | 0.73 | 1.28 |
| Mean malic acid consumption (mg/kg bw/day)a | 0 | 49 | 122 | 223 | 0 | 65 | 145 | 253 |
| Mean aloin A consumption (mg/kg bw/day)a | 0 | 1.59 | 3.95 | 7.21 | 0 | 2.10 | 4.69 | 8.19 |
| Mean aloe-emodin consumption (mg/kg bw/day)a | 0 | 0.02 | 0.04 | 0.08 | 0 | 0.02 | 0.05 | 0.09 |
| Male B6C3F1 Mice | Female B6C3F1 Mice | |||||||
| Aloe vera whole-leaf concentration (wt/wt) | 0% | 1.0% | 2.0% | 3.0% | 0% | 1.0% | 2.0% | 3.0% |
| Mean bw for study (g) | 43.2 | 40.9** | 40.7** | 40.3*** | 36.7 | 37.9 | 37.4 | 35.7 |
| Mean survival for study (weeks) | 94.2 | 97.2 | 93.6 | 93.1 | 101.2 | 98.3 | 101.0 | 97.1 |
| Mean feed intake (g/day) | 6.3 | 6.4 | 6.8* | 6.6 | 5.3 | 5.6 | 5.7** | 5.7** |
| Mean water consumption (g/day) | 7.8 | 12.0*** | 14.2*** | 15.8*** | 5.4 | 8.3*** | 11.7*** | 14.1*** |
| Mean water consumption (g/kg bw/day) | 181 | 294 | 348 | 392 | 147 | 218 | 314 | 394 |
| Mean Aloe vera whole-leaf extract (g/kg bw/day) | 0 | 2.94 | 6.95 | 11.76 | 0 | 2.18 | 6.28 | 11.83 |
| Mean malic acid consumption (mg/kg bw/day)a | 0 | 582 | 1377 | 2329 | 0 | 431 | 1243 | 2343 |
| Mean aloin A consumption (mg/kg bw/day)a | 0 | 16.8 | 39.6 | 67.0 | 0 | 12.41 | 35.79 | 67.44 |
| Mean aloe-emodin consumption (mg/kg bw/day)a | 0 | 0.21 | 0.49 | 0.84 | 0 | 0.15 | 0.45 | 0.84 |
aThe Aloe vera leaf whole extract preparation contained 198mg malic acid/g Aloe vera whole leaf, 5.70mg aloin A/g Aloe vera whole leaf, and 0.07mg aloe-emodin/g Aloe vera whole leaf.
p Values that are significant are annotated with * to indicate p < 0.05, ** to indicate p < 0.01, or *** to indicate p < 0.001.