TABLE 2.
Comparison of Emetic Responses in Mink Following Oral Exposure to 8-Ketotrichothecenes
| Toxin | Dose (mg/kg bw) | Incidence (responding/tested) | Latency to emesis (min)a,b | Emesis duration (min)a,b | Emetic eventsc | ||
|---|---|---|---|---|---|---|---|
| Retching | Vomiting | Total | |||||
| Control | 0 | 0/30 | - | - | 0±0 | 0±0 | 0±0 |
| DON | 0.01 | 0/6 | - | - | 0±0 | 0±0 | 0±0 |
| 0.05* | 5/6 | 15±2 | 1±1 | 12±4 | 3±1 | 15±5 | |
| 0.25* | 6/6 | 17±2 | 6±1 | 44±13 | 8±1 | 52±15 | |
| 0.5* | 6/6 | 11±3 | 14±3 | 62±9 | 9±1 | 71±10 | |
| 3-ADON | 0.05 | 0/6 | - | - | 0±0 | 0±0 | 0±0 |
| 0.25 | 1/6 | 62±0 | 1±0 | 2±2 | 1±1 | 3±3 | |
| 0.5* | 5/6 | 53±9 | 12±9 | 16±8 | 4±1 | 20±9 | |
| 1* | 6/6 | 19±5 | 44±9 | 65±11 | 14±2 | 79±13 | |
| 15-ADON | 0.01 | 0/6 | - | - | 0±0 | 0±0 | 0±0 |
| 0.1* | 5/6 | 20±4 | 1±1 | 9±3 | 2±1 | 11±4 | |
| 0.5* | 6/6 | 18±3 | 3±1 | 24±5 | 6±1 | 30±5 | |
| 1* | 6/6 | 17±4 | 14±7 | 26±5 | 6±1 | 32±6 | |
| FX | 0.01 | 0/6 | - | - | 0±0 | 0±0 | 0±0 |
| 0.05* | 4/6 | 23±2 | 13±10 | 8±3 | 2±1 | 10±4 | |
| 0.25* | 6/6 | 36±10 | 34±11 | 38±5 | 11±2 | 49±7 | |
| 0.5* | 6/6 | 15±3 | 63±21 | 45±4 | 13±2 | 58±4 | |
| NIV | 0.05 | 0/6 | - | - | 0±0 | 0±0 | 0±0 |
| 0.1 | 0/6 | - | - | 0±0 | 0±0 | 0±0 | |
| 0.25* | 4/6 | 31±4 | 15±10 | 21±14 | 4±2 | 25±16 | |
| 0.5* | 6/6 | 29±4 | 32±10 | 55±14 | 9±2 | 64±15 | |
Average of positive responders only.
If animals failed to retch or vomit, the latency and duration of emesis are shown as “-.”
Average of both responders and nonresponders. Data represent the mean ± SEM. Values with an asterisk indicate insignificant differences at p < 0.05 relative to the control for incidence, retching, vomits, and total emetic events.