TABLE 3.

Comparison of Emetic Responses in Mink Following ip and Oral Exposure

Toxin DON	Dose (mg/kg bw)	Incidence (responding/tested)	Latency to emesis (min)a,b	Emesis duration (min)a,b	Emetic eventsc
					Retching	Vomiting	Total
IP	0	0/3	-	-	0±0d	0±0d	0±0d
	0.025	0/3	-	-	0±0d	0±0d	0±0d
	0.05	0/3	-	-	0±0d	0±0d	0±0d
	0.1	2/3	13±2	9±4	37±29e	7±5e	44±35e
	0.25	3/3	11±1	48±4	84±4e	20±1e	105±3e
Oral	0	0/3	-	-	0±0d	0±0d	0±0d
	0.025	0/3	-	-	0±0d	0±0d	0±0d
	0.05	1/3	8±0	7.5±0	24±24e	4±4e	28±28e
	0.1	2/3	14±6	5±0.3	23±14e	7±4e	30±16e
	0.25	3/3	11±3	5±2	44±23e	10±1e	55±24e

^aAverage of positive responders only.

^bIf animals failed to retch or vomit, the latency and duration of emesis is shown as “-.”

^cAverage of both responders and nonresponders. Data represent the mean ± SEM. Values without the same superscript within a column differ (p < 0.05).

^d,eDifferent letters indicate a statistically significant difference between dose groups.