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. 2012 Sep 20;131(1):279–291. doi: 10.1093/toxsci/kfs286

TABLE 4.

Summary of NOAELs, LOAELs, and EDs₅₀ for Emetic Effects of 8-Ketotrichothecenes

	Intraperitoneal			Oral
Toxin	NOAEL^a	LOAEL^b	ED₅₀ ^c	NOAEL^a	LOAEL^b	ED₅₀ ^c
DON	0.05	0.1	0.08 (0.05–0.18)	0.01	0.05	0.03 (0–0.05)
15-ADON	0.1	0.25	0.17 (0.07–0.29)	0.01	0.1	0.04 (0–0.11)
3-ADON	0.1	0.2	0.18 (0.1–0.27)	0.05	0.25	0.29 (0.01–0.47)
FX	0.05	0.1	0.07 (0.04–0.1)	0.01	0.05	0.03 (0.01–0.08)
NIV	0.05	0.1	0.06 (0–0)	0.1	0.25	0.18 (0.1–0.29)

^aNOAEL = no observed adverse effect level.

^bLOAEL = lowest observed adverse effect level.

^cED₅₀ = Dose causing emesis in 50% of the animals tested. ED₅₀ values were determined using a Proc Probit model.