TABLE 5.

Previously Reported Emetic Effects of 8-Ketotrichothecenes

Toxin	Species	Route	NOAEL (mg/kg bw)	LOAEL (mg/kg bw)	References
DON	Pig	ip	n.d.	0.05	Vesonder et al., 1973
DON	Pig	oral	0.075	0.1	Forsyth et al., 1977
		ip	0.025	0.05
DON	Pig	ip	0.025	0.05	Pestka et al., 1987
DON	Pig	oral	0.025	0.05	Prelusky et al., 1993
		iv	0.015	0.02
DON	Dog	sc	n.d.	0.1	Yoshizawa et al., 1974
	Dog	iv	n.d.	0.1
					Yoshizawa et al., 1977
			0.42
15-ADON	Pig	oral	0.05	0.075	Pestka et al., 1987
		ip	0.05	0.075
15-ADON	Dog	sc	n.d	0.2	Yoshizawa et al., 1974
3-ADON	Dog	sc	n.d.	0.2	Yoshizawa et al., 1977
3-ADON	Dog	iv	n.d.	0.2
					Yoshizawa et al., 1977
FX	Dog	iv	n.d	0.1	Matsuoka et al., 1979
FX	Cat	sc	n.d.	1	Ueno et al., 1971
NIV	Dog	iv	n.d.	0.3	Matsuoka et al., 1979