Figure 1.

Representative images of histological sections of livers of normal and chimeric animals stained with hematoxylin and eosin or picrosirius. A: hematoxylin and eosin (HE): shows the central vein (CV), portal vein (PV) and regular hepatocyte plates, representing normal architecture of the liver; B: The PV and CV present inflammatory infiltrate (arrows) due to injury of hepatocytes in this region by CCl₄; C: Picrosirius: collagen (red) is present only in the perivascular region of the PV, hepatic artery (HA) (arrows) and lightly present surrounding the VC; D: a high deposition of collagen surrounding the PV and radiating fibers to the CV, indicating initiation of collagen septa (arrows) formation 30 d after injury induction.