Figure 2.

Effect of p53 absence or inhibition on kidney morphology after IRI. Representative hematoxylin and eosin staining is shown for WT mice treated with vehicle control (A and B) or pifithrin-α (C and D), as well as p53^−/− mice (E and F) after IRI at time points indicated. Tubular necrosis is increased in p53^−/− (49%±6%; P=0.01) and WT mice treated with pifithrin-α (49%±9%; P=0.03) compared with vehicle control-treated WT mice (29%±6%). In addition, tubular cast formation is increased in p53^−/− (26%±3%; P=0.001) and WT mice treated with pifithrin-α (27%±14%; P=0.07) compared with vehicle control-treated WT mice (7%±3%). I/R, ischemia-reperfusion injury; pif, pifithrin-α.