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. 2012 Dec 28;24(1):88–99. doi: 10.1681/ASN.2012050503

Figure 8.

Figure 8.

The prebiotic AXOS reduces plasma PCS and improves metabolic measures in CKD mice. Nephrectomized mice were fed for 4 weeks with a diet containing 5% (wt/wt) of AXOS prebiotic as described in the Concise Methods section. (A) Effect of AXOS on plasma PCS concentration (n=4–5 mice). (B) Weight of different pads of white adipose tissue (WAT). e, epididymal; r, retroperitoneal; sc, subcutaneous. (C) Tissue lipid content in gastrocnemius and liver (n=8). (D) Glucose tolerance test (intraperitoneal); n=6–8 mice. Baseline glucose concentrations were 87±2 and 75±2 mg/dl for control and prebiotic-fed CKD mice, respectively (P<0.001). AUC, area under the curve. (E and F) Insulin tolerance test (n=5 mice). Baseline glucose concentrations were 88±3 and 74±2 mg/dl for control and prebiotic-fed CKD mice, respectively (P<0.001). Data are mean ± SEM. *P<0.05; **P<0.01; ***P<0.001.