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Peptide plane flipping. In the Δ7 crystal form of Sc-HGPRT, the Ile36-Gly37 peptide plane flips between the chain A in closed conformation (A) and the chain B in open conformation (B). Omit maps of electron density encompassing the residues 64–100 of chains A (A) and B (B) at 2.2 Å resolution were contoured at 1.5 σ. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]
