Table 1.
Lack of Correlation of HNP1-3 Concentration with Percent Inhibitory Activity in the Presence of 20% and 50% Amniotic Fluid
| Sample ID | GAa(weeks) | HNP1-3 (pg/ml) | 20% AFb | 50% AFc |
|---|---|---|---|---|
| 1 | 40.7 | 4,187 | 72% | 93% |
| 2 | 38.6 | 7,226 | 0% | 91% |
| 3 | 38.0 | 3,040 | 75% | 90% |
| 4 | 38.7 | 26,283 | 85% | 99% |
| 5 | 39.1 | >250,000 | 0% | 92% |
| 6 | 38.9 | 18,681 | 0% | 98% |
| 7 | 40.0 | 3,700 | 0% | 93% |
| 8 | 38.9 | 5,146 | 68% | 97% |
| 9 | 39.0 | <41 | 0% | 97% |
| 10A | 36.8 | <41 | 66% | 93% |
| 10B | 36.9 | <41 | 62% | 96% |
| 11 | 38.3 | 9,833 | 0% | 98% |
| 12 | 39.1 | 5,187 | 40% | 97% |
Gestational age (GA) at the time of delivery.
Percent inhibitory effect of 20% amniotic fluid (AF) on day 4 of infection.
Percent inhibitory effect of 50% amniotic fluid on day 4 of infection.
A total of 13 AF samples were collected from 12 women at term (36.9â40.7 weeks). Patient 10 had two samples collected: sample A during amniocentesis and sample B collected at the time of cesarean section. At 20% AF, samples from half of the subjects and at 50% samples from all subjects exhibited significant anti-HIV activity as determined on day 4 of infection. HNP1-3 concentration was highly variable and ranged from undetectable to >250,000âpg/ml.