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. Author manuscript; available in PMC: 2013 Jan 4.
Published in final edited form as: Hypertension. 2010 Jul 26;56(3):505–511. doi: 10.1161/HYPERTENSIONAHA.110.152256

Figure 4. FEN reduces intracellular sodium accumulation in i14 and i16 but not in HK-2, i2, or i25 cell lines.

Figure 4

Intracellular sodium concentration was determined using the sodium sensitive dye SBFI. The ouabain (OUB, 100 µmol/L plus vehicle, VEH)increased intracellular accumulation, by inhibition of sodium efflux via NaKATPase, was linear over a 30 minute time interval. OUB + FEN (1 µmol/L) reduced Na+ accumulation (*P<0.05, N=6) in only the i14 (□) and i16 (x) coupled cell lines.