Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Flow diagram of immune development leading to allergic sensitization with known expression of estrogen receptors by each immune cell type. Environmental estrogens (EEs) have potential effects on each step of allergic sensitization: antigen presentation, Th2 polarization, isotype switching to IgE and mast cell degranulation via ERα, ERβ and G-protein coupled receptor 30 (GPR30) [14,15▪,16–18,19▪▪,20–22,23▪,24,25]. ER, estrogen receptor; IgE, immunoglobulin E.
